Controlled release systems for DNA delivery
نویسندگان
چکیده
منابع مشابه
Controlled release systems for DNA delivery.
Adapting controlled release technologies to the delivery of DNA has the potential to overcome extracellular barriers that limit gene therapy. Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods (e.g., injection). These systems typically deliver vectors locally, which can avoid distributio...
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Tri-block poly (lactide) poly(ethylene glycol) poly(lactide) (PLA–PEG–PLA) copolymers are among the most attractive nano-carriers for gene delivery into mammalian cells, due to their biocompatibility and biodegradability properties. However, the low efficiency of the gene delivery by these copolymers is an obstacle to gene therapy. Here, we have investigated nanoparticles formulated using the p...
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Controlled release drug delivery systems 1 are those dosage formulations designed to release an active ingredient at rates, which differ significantly from their corresponding conventional dosage forms. The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the delivery of the drug to a ti...
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22.1 PHYSICOCHEMICAL PROPERTIES OF 22.7 BIODEGRADABLE/ERODIBLE DRUG 22.2 DELIVERY SYSTEMS 22.9 22.2 ROUTES OF DRUG 22.8 OSMOTIC PUMP 22.10 ADMINISTRATION 22.3 22.9 ION EXCHANGE RESINS 22.11 22.3 PHARMACOLOGICAL AND 22.10 NEW MACROMOLECULAR DELIVERY BIOLOGICAL EFFECTS 22.4 APPROACHES 22.12 22.4 PRODRUG 22.4 22.11 CONCLUSION 22.14 22.5 DIFFUSION-CONTROLLED DELIVERY REFERENCES 22.14 SYSTEMS 22.5 2...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2004
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2004.03.020